HFM1

Entrez Summary: The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014].
UniProt Summary: Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. {ECO:0000250|UniProtKB:D3Z4R1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

resolution of meiotic recombination intermediates
meiotic chromosome separation
chromosome separation
reciprocal meiotic recombination
homologous recombination
DNA helicase activity
meiotic chromosome segregation
meiosis I
DNA duplex unwinding
meiosis I cell cycle process
DNA geometric change
meiotic nuclear division
meiotic cell cycle process
nucleic acid binding
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
chromosome segregation
nuclear division
DNA conformation change
organelle fission
DNA metabolic process
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
ATP binding