HLCS
Gene Information
- Official Symbol: HLCS
- Official Name: holocarboxylase synthetase
- Aliases and Previous Symbols: N/A
- Entrez ID: 3141
- UniProt: P50747
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011].
- UniProt Summary: Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5691
- Expression level (log2 read counts): 4.02
HLCS Expression in NALM6 Cells: 4.02
