HNRNPR

Entrez Summary: N/A
UniProt Summary: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Doxorubicin 0.02μM R08 exp478	-1.8
Hypoxia 5%O2 R04 exp191	-1.77
Rapamycin 1μM R00 exp29	-1.77
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.74
UNC2400 2μM R03 exp156	-1.72
Hydroxyurea 100μM R07 exp329	1.79

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mRNA destabilization
RNA destabilization
positive regulation of mRNA catabolic process
axon terminus
mRNA 3-UTR binding
positive regulation of mRNA metabolic process
catalytic step 2 spliceosome
spliceosomal complex
growth cone
negative regulation of translation
circadian rhythm
negative regulation of cellular amide metabolic process
ribonucleoprotein complex
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
rhythmic process
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
regulation of translation
positive regulation of cellular catabolic process
RNA splicing
regulation of cellular amide metabolic process
dendrite
positive regulation of catabolic process
mRNA processing
posttranscriptional regulation of gene expression
mRNA metabolic process
negative regulation of catalytic activity
regulation of cellular catabolic process
nucleolus
RNA processing
regulation of catabolic process
endoplasmic reticulum
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function