HRH2

Entrez Summary: N/A
UniProt Summary: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 1
7TM GPCR Srsx

gastrin-induced gastric acid secretion
histamine-induced gastric acid secretion
histamine receptor activity
gastric acid secretion
positive regulation of vasoconstriction
epithelial cell morphogenesis
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
toxin transport
serotonin receptor signaling pathway
visual learning
visual behavior
regulation of vasoconstriction
positive regulation of blood circulation
digestive system process
associative learning
acid secretion
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
digestion
memory
cellular response to ammonium ion
digestive tract development
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
digestive system development
learning
vascular process in circulatory system
response to ammonium ion
regulation of synaptic plasticity
epithelial cell development
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
learning or memory