IGJ

Entrez Summary: N/A
UniProt Summary: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. {ECO:0000250|UniProtKB:P01592}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	-1.86
Oligomycin-A 20μM R00 exp26	1.89

dimeric IgA immunoglobulin complex
hexameric IgM immunoglobulin complex
pentameric IgM immunoglobulin complex
secretory dimeric IgA immunoglobulin complex
IgA binding
monomeric IgA immunoglobulin complex
secretory IgA immunoglobulin complex
positive regulation of respiratory burst
glomerular filtration
renal filtration
regulation of respiratory burst
peptidoglycan binding
positive regulation of protein oligomerization
phosphatidylcholine binding
antibacterial humoral response
regulation of protein oligomerization
retina homeostasis
protein binding, bridging
immunoglobulin receptor binding
single-stranded DNA binding
renal system process
antimicrobial humoral response
blood microparticle
antigen binding
tissue homeostasis
receptor-mediated endocytosis
positive regulation of protein complex assembly
multicellular organismal homeostasis
defense response to bacterium
anatomical structure homeostasis
humoral immune response
leukocyte migration
regulation of protein complex assembly
positive regulation of cellular component biogenesis
endocytosis
adaptive immune response
import into cell
response to bacterium
innate immune response
protein homodimerization activity