ITIH3

Entrez Summary: N/A
UniProt Summary: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet dense granule lumen
hyaluronan metabolic process
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
mucopolysaccharide metabolic process
platelet degranulation
glycosaminoglycan metabolic process
aminoglycan metabolic process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulated exocytosis
regulation of proteolysis
negative regulation of catalytic activity
exocytosis
carboxylic acid metabolic process
oxoacid metabolic process
secretion by cell
organic acid metabolic process
carbohydrate derivative metabolic process
negative regulation of cellular protein metabolic process
export from cell
negative regulation of protein metabolic process
secretion
negative regulation of molecular function
regulation of hydrolase activity
small molecule metabolic process
extracellular region
vesicle-mediated transport