ITPA

Gene Information

Official Symbol: ITPA
Official Name: inosine triphosphatase
Aliases and Previous Symbols: N/A
Entrez ID: 3704
UniProt: Q9BY32
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
UniProt Summary: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Erlotinib 10μM R05 exp216	-3.04
Rucaparib 6.5μM R08 exp520	-2.62
Olaparib 4μM R08 exp512	-2.54
Hypoxia 5%O2 R04 exp191	-2.01
Calcipotriol 5μM R08 exp464	-1.99
Talazoparib 0.006μM R06 exp299	-1.96
5-Fluorouracil 2μM R00 exp1	-1.76
LB-100 2μM R05 exp210	-1.73
ABT-702 5μM R07 exp318	-1.7
Sulforaphane 9μM R08 exp526 no dilution day6	2.02
MLN-4924 2μM R00 exp22	2.19

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10676
Expression level (log2 read counts): 5.12

Expression Distribution

Gene	Correlation
RNASEH2B	0.484
ELP2	0.443
EIF1AX	0.412
URM1	0.4

ITP catabolic process
purine ribonucleoside triphosphate catabolic process
ribonucleoside triphosphate catabolic process
dITP diphosphatase activity
ITP metabolic process
purine nucleoside triphosphate catabolic process
nucleoside-triphosphate diphosphatase activity
NADH pyrophosphatase activity
deoxyribonucleoside triphosphate catabolic process
nucleoside triphosphate catabolic process
deoxyribonucleoside triphosphate metabolic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
purine ribonucleoside triphosphate metabolic process
nucleotide binding
nucleotide catabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
nucleoside phosphate catabolic process
nucleoside triphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process