IZUMO1

Entrez Summary: N/A
UniProt Summary: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.001μM R01 exp42	-1.81
Losmapimod 1μM R07 exp376	-1.71

protein binding involved in heterotypic cell-cell adhesion
fusion of sperm to egg plasma membrane involved in single fertilization
acrosomal membrane
plasma membrane fusion
heterotypic cell-cell adhesion
sperm-egg recognition
cell-cell recognition
membrane fusion
single fertilization
fertilization
cell recognition
signaling receptor binding
cellular process involved in reproduction in multicellular organism
cell-cell adhesion
sexual reproduction
multicellular organism reproduction
membrane organization
protein homodimerization activity
cell adhesion
biological adhesion
multi-organism reproductive process
reproductive process
reproduction