KCNJ3

Gene Information

Official Symbol: KCNJ3
Official Name: potassium inwardly rectifying channel subfamily J member 3
Aliases and Previous Symbols: N/A
Entrez ID: 3760
UniProt: P48549
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14686
Expression level (log2 read counts): 3.03

Expression Distribution

Screen	Score
VE-822 0.04μM R06 exp300	-1.76
Selumetinib 20μM R02 exp81	1.84

G-protein activated inward rectifier potassium channel activity
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
membrane repolarization during atrial cardiac muscle cell action potential
atrial cardiac muscle cell membrane repolarization
membrane repolarization during ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
atrial cardiac muscle cell to AV node cell signaling
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
parallel fiber to Purkinje cell synapse
cardiac muscle cell membrane repolarization
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
inward rectifier potassium channel activity
ventricular cardiac muscle cell action potential
membrane repolarization
cell-cell signaling involved in cardiac conduction
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
T-tubule
response to electrical stimulus
potassium ion import across plasma membrane
cell communication involved in cardiac conduction
cardiac muscle cell action potential
integral component of presynaptic membrane
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
cardiac muscle contraction
voltage-gated potassium channel complex
heart contraction
actin-mediated cell contraction
cardiac conduction
action potential
import across plasma membrane
regulation of heart rate
heart process
striated muscle contraction
actin filament-based movement