KCNMB2

Official Symbol: KCNMB2
Official Name: potassium calcium-activated channel subfamily M regulatory beta subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 10242
UniProt: Q9Y691
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-47 25μM R04 exp182	-1.79
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.77

CaKB
KcnmB2 inactiv

ion channel inhibitor activity
detection of calcium ion
calcium-activated potassium channel activity
neuronal action potential
potassium channel regulator activity
transmission of nerve impulse
regulation of vasoconstriction
voltage-gated potassium channel complex
action potential
multicellular organismal signaling
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
response to calcium ion
potassium ion transmembrane transport
potassium ion transport
vascular process in circulatory system
regulation of blood circulation
response to metal ion
blood circulation
circulatory system process
monovalent inorganic cation transport
regulation of membrane potential
regulation of anatomical structure size
detection of chemical stimulus
response to inorganic substance
inorganic cation transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
cation transport
ion transmembrane transport
transmembrane transport
ion transport
nervous system process
integral component of plasma membrane
system process