KDELR2

Entrez Summary: N/A
UniProt Summary: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KDEL sequence binding
COPI-coated vesicle membrane
protein retention in ER lumen
maintenance of protein localization in endoplasmic reticulum
maintenance of protein localization in organelle
cis-Golgi network
maintenance of protein location in cell
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
transport vesicle
maintenance of location in cell
maintenance of protein location
protein localization to endoplasmic reticulum
maintenance of location
endoplasmic reticulum to Golgi vesicle-mediated transport
Golgi vesicle transport
Golgi membrane
protein localization to organelle
endoplasmic reticulum membrane
Golgi apparatus
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport