KDM4D

Entrez Summary: N/A
UniProt Summary: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-395 10μM R05 exp218	1.83
Dimethyloxaloylglycine 100μM R05 exp229	1.88
L-BMAA 500 to 750μM on day4 R04 exp185	1.89
Pyronaridine 1μM R06 exp295	2.09

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

JmjC
JmjN

negative regulation of histone H3-K9 trimethylation
negative regulation of histone H3-K9 methylation
regulation of histone H3-K9 trimethylation
positive regulation of chromatin binding
positive regulation of double-strand break repair via nonhomologous end joining
histone demethylase activity (H3-K9 specific)
pericentric heterochromatin
histone demethylase activity
histone H3-K9 demethylation
negative regulation of histone methylation
regulation of chromatin binding
regulation of histone H3-K9 methylation
dioxygenase activity
regulation of double-strand break repair via nonhomologous end joining
histone lysine demethylation
histone demethylation
positive regulation of double-strand break repair
protein demethylation
protein dealkylation
negative regulation of histone modification
histone methyltransferase complex
damaged DNA binding
site of double-strand break
negative regulation of chromatin organization
demethylation
regulation of histone methylation
positive regulation of DNA repair
cellular response to ionizing radiation
chromatin DNA binding
regulation of double-strand break repair
double-strand break repair via homologous recombination
recombinational repair
positive regulation of response to DNA damage stimulus
regulation of DNA repair
negative regulation of chromosome organization
blood microparticle
regulation of histone modification
response to ionizing radiation
chromatin remodeling
cellular response to radiation