KIAA1804

Gene Information

Official Symbol: MAP3K21
Official Name: mitogen-activated protein kinase kinase kinase 21
Aliases and Previous Symbols: N/A
Entrez ID: 84451
UniProt: Q5TCX8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13032
Expression level (log2 read counts): N/A

Expression Distribution

Screen	Score
Quinacrine 2.5μM R03 exp146	-1.89
Cincreasin 100μM R08 exp473	-1.75

SH3 2
Pkinase Tyr
SH3 1
Pkinase

MAP kinase kinase kinase activity
activation of JUN kinase activity
activation of MAPKK activity
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
stress-activated MAPK cascade
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
protein autophosphorylation
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
cellular component
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of cellular response to stress
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein homodimerization activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process