KLF9

Entrez Summary: N/A
UniProt Summary: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835). {ECO:0000269|PubMed:22711835}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to cortisol stimulus
response to cortisol
negative regulation of keratinocyte proliferation
cellular response to thyroid hormone stimulus
response to thyroid hormone
regulation of keratinocyte proliferation
cellular response to glucocorticoid stimulus
cellular response to corticosteroid stimulus
cellular response to alcohol
cellular response to ketone
negative regulation of epithelial cell proliferation
circadian rhythm
response to glucocorticoid
response to corticosteroid
cellular response to steroid hormone stimulus
response to ketone
response to alcohol
rhythmic process
response to steroid hormone
regulation of epithelial cell proliferation
cellular response to drug
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
DNA-binding transcription factor activity
negative regulation of cell population proliferation
response to lipid
response to hormone
response to organic cyclic compound
response to drug
cellular response to oxygen-containing compound
cellular response to endogenous stimulus
DNA binding
response to endogenous stimulus
response to oxygen-containing compound
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation