KLLN
Gene Information
- Official Symbol: KLLN
- Official Name: killin, p53 regulated DNA replication inhibitor
- Aliases and Previous Symbols: N/A
- Entrez ID: 100144748
- UniProt: B2CW77
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012].
- UniProt Summary: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single- stranded DNA. {ECO:0000269|PubMed:18385383}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5344
- Expression level (log2 read counts): 2.77
KLLN Expression in NALM6 Cells: 2.77
