KLRF2

Entrez Summary: N/A
UniProt Summary: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. {ECO:0000269|PubMed:20194751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-1.92
Lead acetate 2000μM R08 exp498 no dilution day6	-1.75
DABN racemic mixture R03 exp93	2.06

natural killer cell degranulation
natural killer cell activation involved in immune response
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
leukocyte mediated cytotoxicity
cytokine secretion
natural killer cell activation
cell killing
lymphocyte activation involved in immune response
cytokine production
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
carbohydrate binding
lymphocyte mediated immunity
lymphocyte activation
leukocyte degranulation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
innate immune response
leukocyte mediated immunity
exocytosis
protein homodimerization activity
leukocyte activation
defense response to other organism
secretion by cell
export from cell
cell activation
immune effector process
secretion
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
integral component of plasma membrane
protein transport
peptide transport
amide transport