LCAT

Entrez Summary: This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). {ECO:0000269|PubMed:10329423, ECO:0000269|PubMed:10722751, ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:8820107}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
D-Fructose 10000μM R06 exp279	-1.81
Nifuroxazide 1μM R01 exp51	2.15

Abhydrolase 6
LACT

phosphatidylcholine-sterol O-acyltransferase activity
regulation of high-density lipoprotein particle assembly
sterol esterification
steroid esterification
cholesterol esterification
apolipoprotein A-I binding
very-low-density lipoprotein particle remodeling
triglyceride-rich lipoprotein particle remodeling
reverse cholesterol transport
high-density lipoprotein particle remodeling
high-density lipoprotein particle
protein-lipid complex remodeling
plasma lipoprotein particle remodeling
protein-containing complex remodeling
phosphatidylcholine biosynthetic process
plasma lipoprotein particle organization
protein-lipid complex subunit organization
cholesterol transport
sterol transport
regulation of plasma lipoprotein particle levels
phosphatidylcholine metabolic process
cholesterol homeostasis
sterol homeostasis
lipoprotein biosynthetic process
cholesterol metabolic process
lipoprotein metabolic process
secondary alcohol metabolic process
lipid homeostasis
sterol metabolic process
organic hydroxy compound transport
ammonium ion metabolic process
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
steroid metabolic process
lipid transport
glycerophospholipid metabolic process
alcohol metabolic process
lipid localization