LIPE

Entrez Summary: The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008].
UniProt Summary: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cabazitaxel 0.001μM R05 exp223	1.7
Colchicine 0.009μM R05 exp215	1.71

Abhydrolase 3
HSL N

hormone-sensitive lipase activity
diacylglycerol catabolic process
serine hydrolase activity
long-chain fatty acid catabolic process
triglyceride lipase activity
diacylglycerol metabolic process
triglyceride catabolic process
acylglycerol catabolic process
neutral lipid catabolic process
glycerolipid catabolic process
caveola
triglyceride metabolic process
lipid droplet
fatty acid catabolic process
acylglycerol metabolic process
neutral lipid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
cholesterol metabolic process
secondary alcohol metabolic process
sterol metabolic process
cellular lipid catabolic process
steroid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
alcohol metabolic process
fatty acid metabolic process
glycerolipid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
protein kinase binding
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
protein phosphorylation
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
phosphorylation