LMO3

Gene Information

Official Symbol: LMO3
Official Name: LIM domain only 3
Aliases and Previous Symbols: N/A
Entrez ID: 55885
UniProt: Q8TAP4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	1.7
UNC2400 2μM R03 exp156	1.7
GSK591 2.6μM R03 exp128	1.72
YM155 0.001μM R08 exp432	1.72
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18691
Expression level (log2 read counts): 0.61

Expression Distribution

positive regulation of glucocorticoid receptor signaling pathway
regulation of glucocorticoid receptor signaling pathway
positive regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of intracellular steroid hormone receptor signaling pathway
regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of fat cell differentiation
negative regulation of ERK1 and ERK2 cascade
regulation of intracellular steroid hormone receptor signaling pathway
regulation of fat cell differentiation
negative regulation of MAPK cascade
regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
positive regulation of cell differentiation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
positive regulation of signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of cell differentiation
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process