LRP1B

Entrez Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].
UniProt Summary: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 13μM R08 exp465	-2.23
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.88
Vemurafenib 6.6μM R08 exp434	-1.82
2-Deoxy-D-glucose 800μM R05 exp214	1.72
Dimethyloxaloylglycine 11μM R07 exp314	1.74
GSK626616 14μM R08 exp485	1.75
Resveratrol 16μM R03 exp147	1.75
THZ1 0.06μM R08 exp531	1.82
Hydroxychloroquine 30μM R08 exp490	1.83
GSK-J4 1.5μM R08 exp441	2.13

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

receptor complex
receptor-mediated endocytosis
endocytosis
import into cell
calcium ion binding
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport
vesicle-mediated transport