LRRC16A

Gene Information

Official Symbol: CARMIL1
Official Name: capping protein regulator and myosin 1 linker 1
Aliases and Previous Symbols: N/A
Entrez ID: 55604
UniProt: Q5VZK9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.74
Clomiphene 4.4μM R02 exp68	-2.7
Nocodazole 0.2μM R00 exp24	-2.27
GSK-J5 1.5μM R08 exp484	-2.16
Rotenone 2μM R00 exp33	-1.94
CCCP 1μM R00 exp11	-1.9
Nifuroxazide 5μM R03 exp102	-1.84
5-Fluorouracil 2μM R00 exp1	-1.75
DABN 20μM R00 exp17	-1.74
Apcin 25μM plus proTAME 2μM R04 exp177	1.81

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13699
Expression level (log2 read counts): 2.99

Expression Distribution

barbed-end actin filament uncapping
actin filament uncapping
negative regulation of barbed-end actin filament capping
regulation of barbed-end actin filament capping
actin filament network formation
macropinocytosis
macropinosome
pinocytosis
urate metabolic process
positive regulation of actin filament depolymerization
positive regulation of protein depolymerization
ruffle organization
positive regulation of lamellipodium organization
filamentous actin
lamellipodium assembly
positive regulation of protein complex disassembly
positive regulation of substrate adhesion-dependent cell spreading
lamellipodium organization
regulation of lamellipodium organization
cell leading edge
positive regulation of stress fiber assembly
regulation of actin filament depolymerization
regulation of substrate adhesion-dependent cell spreading
positive regulation of actin filament bundle assembly
regulation of stress fiber assembly
regulation of protein depolymerization
regulation of actomyosin structure organization
positive regulation of actin filament polymerization
regulation of actin filament bundle assembly
regulation of protein complex disassembly
positive regulation of cell-substrate adhesion
positive regulation of protein polymerization
positive regulation of cell morphogenesis involved in differentiation
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of cell-substrate adhesion
positive regulation of cytoskeleton organization