LTBR

Gene Information

Official Symbol: LTBR
Official Name: lymphotoxin beta receptor
Aliases and Previous Symbols: N/A
Entrez ID: 4055
UniProt: P36941
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012].
UniProt Summary: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000269|PubMed:10799510, ECO:0000269|PubMed:8171323}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RK-33 8μM R08 exp518	-2.04
Disulfiram 4.3μM R06 exp281	-2.01
Geldanamycin 0.01μM R05 exp235	1.71
IU1-47 25μM R04 exp182	1.72
B02 10μM R08 exp453	1.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4724
Expression level (log2 read counts): 3.22

Expression Distribution

myeloid dendritic cell differentiation
myeloid dendritic cell activation
dendritic cell differentiation
positive regulation of extrinsic apoptotic signaling pathway
cellular response to mechanical stimulus
myeloid leukocyte differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of JNK cascade
regulation of extrinsic apoptotic signaling pathway
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of apoptotic signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of JNK cascade
response to mechanical stimulus
myeloid cell differentiation
regulation of stress-activated MAPK cascade
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of stress-activated protein kinase signaling cascade
cellular response to tumor necrosis factor
response to tumor necrosis factor
ubiquitin protein ligase binding
cellular response to abiotic stimulus
cellular response to environmental stimulus
leukocyte differentiation
cellular response to external stimulus
regulation of apoptotic signaling pathway
positive regulation of MAPK cascade
hemopoiesis
myeloid leukocyte activation
hematopoietic or lymphoid organ development
positive regulation of apoptotic process
positive regulation of programmed cell death
immune system development
cytokine-mediated signaling pathway
positive regulation of cell death
viral process
regulation of cellular response to stress
regulation of MAPK cascade
symbiotic process