LY96

Gene Information

Official Symbol: LY96
Official Name: lymphocyte antigen 96
Aliases and Previous Symbols: N/A
Entrez ID: 23643
UniProt: Q9Y6Y9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11160242, ECO:0000269|PubMed:11593030, ECO:0000269|PubMed:17569869, ECO:0000269|PubMed:17803912}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cadmium 60μM R08 exp462	-2.34
BI-6727 0.0125μM R03 exp97	-1.85
Dimethyl-Sulfoxide 1pc R03 exp120	-1.83
BRD2 inhibitor II 20μM R07 exp341	1.71
Salubrinal 20μM R07 exp399	1.75
BS-181 20μM R08 exp461	1.86
Deguelin 0.05μM R02 exp69	1.88
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18999
Expression level (log2 read counts): 0.8

Expression Distribution

detection of lipopolysaccharide
lipopolysaccharide receptor complex
lipopolysaccharide receptor activity
Toll-like receptor 4 binding
negative regulation of MyD88-independent toll-like receptor signaling pathway
regulation of MyD88-independent toll-like receptor signaling pathway
positive regulation of lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
toll-like receptor 4 signaling pathway
detection of external biotic stimulus
detection of biotic stimulus
necroptotic process
regulation of lipopolysaccharide-mediated signaling pathway
programmed necrotic cell death
TRIF-dependent toll-like receptor signaling pathway
necrotic cell death
MyD88-independent toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
lipopolysaccharide-mediated signaling pathway
coreceptor activity
lipopolysaccharide binding
intrinsic component of plasma membrane
negative regulation of toll-like receptor signaling pathway
cellular defense response
regulation of toll-like receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
endosome membrane
cellular response to biotic stimulus
innate immune response-activating signal transduction
activation of innate immune response
apoptotic signaling pathway
response to lipopolysaccharide