MAGEC2

Entrez Summary: This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009].
UniProt Summary: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

MAGE
MAGE N

positive regulation of ubiquitin-protein transferase activity
regulation of ubiquitin-protein transferase activity
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
ubiquitin protein ligase binding
cellular protein catabolic process
positive regulation of transferase activity
protein catabolic process
nucleolus
cellular macromolecule catabolic process
regulation of transferase activity
macromolecule catabolic process
organonitrogen compound catabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
organic substance catabolic process
positive regulation of molecular function
cellular catabolic process
regulation of protein modification process