MAN2A1

Entrez Summary: N/A
UniProt Summary: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenic trioxide 60μM R08 exp449	-2.23
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.13
2-Deoxy-D-glucose 800μM R05 exp214	-1.82
Cabazitaxel 0.001μM R05 exp223	1.87
MLN-4924 2μM R00 exp22	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydrolase activity, hydrolyzing N-glycosyl compounds
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
alpha-mannosidase activity
mannose metabolic process
Golgi medial cisterna
N-glycan processing
protein deglycosylation
lung alveolus development
respiratory gaseous exchange by respiratory system
retina morphogenesis in camera-type eye
cis-Golgi network
camera-type eye morphogenesis
liver development
hepaticobiliary system development
vacuole organization
retina development in camera-type eye
eye morphogenesis
hexose metabolic process
lung development
respiratory tube development
carbohydrate binding
respiratory system development
monosaccharide metabolic process
sensory organ morphogenesis
protein glycosylation
macromolecule glycosylation
glycosylation
camera-type eye development
glycoprotein biosynthetic process
eye development
visual system development
sensory system development
in utero embryonic development
glycoprotein metabolic process
gland development
mitochondrion organization
positive regulation of neurogenesis
carbohydrate metabolic process
positive regulation of nervous system development
positive regulation of cell development