MDK
Gene Information
- Official Symbol: MDK
- Official Name: midkine
- Aliases and Previous Symbols: N/A
- Entrez ID: 4192
- UniProt: P21741
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:1768439}.
Pfam Domains GO Terms
Pfam Domains
| PTN MK C |
| PTN MK N |
GO Terms
| defecation |
| glial cell projection elongation |
| positive regulation of inflammatory response to wounding |
| positive regulation blood vessel branching |
| heparan sulfate binding |
| negative regulation of inflammatory response to wounding |
| regulation of artery morphogenesis |
| positive regulation of smooth muscle cell chemotaxis |
| positive regulation of artery morphogenesis |
| regulation of inflammatory response to wounding |
| regulation of blood vessel branching |
| positive regulation of interleukin-12 secretion |
| leukocyte chemotaxis involved in inflammatory response |
| negative regulation of regulatory T cell differentiation |
| positive regulation of neutrophil extravasation |
| regulation of smooth muscle cell chemotaxis |
| regulation of interleukin-12 secretion |
| regulation of neutrophil extravasation |
| positive regulation of hepatocyte proliferation |
| short-term memory |
| chondroitin sulfate binding |
| positive regulation of keratinocyte proliferation |
| cerebellar granular layer development |
| positive regulation of leukocyte adhesion to vascular endothelial cell |
| leukocyte migration involved in inflammatory response |
| regulation of hepatocyte proliferation |
| positive regulation of macrophage chemotaxis |
| positive regulation of vascular endothelial cell proliferation |
| positive regulation of neuron migration |
| dentate gyrus development |
| positive regulation of cellular extravasation |
| estrous cycle |
| regulation of leukocyte adhesion to vascular endothelial cell |
| regulation of vascular endothelial cell proliferation |
| positive regulation of macrophage migration |
| negative regulation of cardiac muscle cell apoptotic process |
| positive regulation of oligodendrocyte differentiation |
| positive regulation of neutrophil chemotaxis |
| adrenal gland development |
| negative regulation of striated muscle cell apoptotic process |
| positive regulation of granulocyte chemotaxis |
| regulation of macrophage chemotaxis |
| response to auditory stimulus |
| regulation of neutrophil chemotaxis |
| positive regulation of neutrophil migration |
| regulation of cellular extravasation |
| behavioral fear response |
| regulation of regulatory T cell differentiation |
| behavioral defense response |
| regulation of keratinocyte proliferation |
| fear response |
| positive regulation of cartilage development |
| positive regulation of morphogenesis of an epithelium |
| positive regulation of interleukin-12 production |
| regulation of neutrophil migration |
| positive regulation of substrate adhesion-dependent cell spreading |
| positive regulation of smooth muscle cell migration |
| regulation of actin cytoskeleton reorganization |
| negative regulation of muscle cell apoptotic process |
| regulation of cardiac muscle cell apoptotic process |
| regulation of macrophage migration |
| regulation of oligodendrocyte differentiation |
| regulation of striated muscle cell apoptotic process |
| excretion |
| negative regulation of epithelial cell apoptotic process |
| positive regulation of glial cell differentiation |
| regulation of neuron migration |
| regulation of granulocyte chemotaxis |
| negative regulation of T cell differentiation |
| regulation of mononuclear cell migration |
| cerebellar cortex development |
| positive regulation of epithelial to mesenchymal transition |
| regulation of bone remodeling |
| regulation of chondrocyte differentiation |
| positive regulation of neural precursor cell proliferation |
| regulation of substrate adhesion-dependent cell spreading |
| negative regulation of lymphocyte differentiation |
| regulation of interleukin-12 production |
| regulation of morphogenesis of a branching structure |
| regulation of smooth muscle cell migration |
| tissue regeneration |
| positive regulation of response to wounding |
| T cell activation involved in immune response |
| ovulation cycle |
| regulation of muscle cell apoptotic process |
| multicellular organismal response to stress |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| regulation of cartilage development |
| regulation of behavior |
| regulation of tissue remodeling |
| negative regulation of ossification |
| oogenesis |
| regulation of epithelial cell apoptotic process |
| positive regulation of animal organ morphogenesis |
| hippocampus development |
| positive regulation of T cell differentiation |
| regulation of epithelial to mesenchymal transition |
| negative regulation of response to wounding |
| positive regulation of cell division |
| regulation of neural precursor cell proliferation |
| positive regulation of leukocyte chemotaxis |
| positive regulation of lymphocyte differentiation |
| positive regulation of endothelial cell proliferation |
| cell projection |
| negative regulation of leukocyte differentiation |
| cerebellum development |
| glial cell development |
| limbic system development |
| lymphocyte activation involved in immune response |
| negative regulation of T cell activation |
| metencephalon development |
| regulation of leukocyte chemotaxis |
| regulation of gliogenesis |
| cerebral cortex development |
| memory |
| endocrine system development |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of cell-substrate adhesion |
| Notch signaling pathway |
| regulation of endothelial cell proliferation |
| positive regulation of leukocyte migration |
| female gamete generation |
| positive regulation of chemotaxis |
| negative regulation of inflammatory response |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| positive regulation of cytokine secretion |
| positive regulation of inflammatory response |
| response to glucocorticoid |
| leukocyte chemotaxis |
| negative regulation of lymphocyte activation |
| negative regulation of neuron apoptotic process |
| positive regulation of leukocyte differentiation |
| hindbrain development |
| positive regulation of cell morphogenesis involved in differentiation |
| regeneration |
| response to corticosteroid |
| positive regulation of angiogenesis |
| growth factor activity |
| regulation of response to wounding |
| regulation of cell division |
| regulation of lymphocyte differentiation |
| heparin binding |
| glial cell differentiation |
| pallium development |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| negative regulation of canonical Wnt signaling pathway |
| regulation of morphogenesis of an epithelium |
| positive regulation of vasculature development |
| positive regulation of hemopoiesis |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| negative regulation of defense response |
| negative regulation of Wnt signaling pathway |
| cell chemotaxis |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| response to mechanical stimulus |
| gliogenesis |
| positive regulation of leukocyte cell-cell adhesion |
| T cell activation |
| positive regulation of cell-cell adhesion |
| germ cell development |
| telencephalon development |
| regulation of animal organ morphogenesis |
| learning or memory |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| rhythmic process |
| positive regulation of neuron projection development |
| regulation of canonical Wnt signaling pathway |
| regulation of angiogenesis |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| cognition |
| regulation of cell morphogenesis involved in differentiation |
| regulation of neuron death |
| regulation of T cell activation |
| regulation of vasculature development |
| response to steroid hormone |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| regulation of actin cytoskeleton organization |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of lymphocyte activation |
| regulation of Wnt signaling pathway |
| collagen-containing extracellular matrix |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| leukocyte migration |
| positive regulation of cell projection organization |
| lymphocyte activation |
| forebrain development |
| regulation of actin filament-based process |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| gland development |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| wound healing |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| inflammatory response |
| positive regulation of cell migration |
| cell part morphogenesis |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| response to wounding |
| behavior |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| regulation of cell adhesion |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| head development |
| regulation of secretion |
| regulation of neurogenesis |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| regulation of cellular component movement |
| response to drug |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| regulation of response to external stimulus |
| cytoskeleton organization |
| positive regulation of immune system process |
| cell projection organization |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| negative regulation of signal transduction |
| regulation of organelle organization |
| locomotion |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxyurea 15μM R06 exp289 | 2.06 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.425 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12038
- Expression level (log2 read counts): 6.42
Expression Distribution
MDK Expression in NALM6 Cells: 6.42
