MGAT2

Official Symbol: MGAT2
Official Name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 4247
UniProt: Q10469
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.84
Metformin 100 to 150μM on day4 R04 exp170	-1.79
Cidofovir 10μM R07 exp345	-1.77
Azithromycin 100μM R08 exp452	-1.76
2-Deoxy-D-glucose 800μM R05 exp214	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
oligosaccharide biosynthetic process
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
Golgi stack
oligosaccharide metabolic process
manganese ion binding
protein N-linked glycosylation
carbohydrate biosynthetic process
carbohydrate binding
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
protein homodimerization activity
peptidyl-amino acid modification
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane