MKL2

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TIC10 10μM R08 exp532	1.88
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.91
Fas-L 44ng/ml R08 exp482	2.03
NFN1 0.4μM R03 exp99	2.11

RPEL
SAP

smooth muscle cell differentiation
positive regulation of muscle organ development
positive regulation of striated muscle tissue development
positive regulation of muscle tissue development
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
muscle cell differentiation
transcription coactivator activity
muscle organ development
cadherin binding
muscle structure development
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of multicellular organismal process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process