MRPL14

Entrez Summary: N/A
UniProt Summary: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vitamin-D3 40μM R08 exp536	-2.13
LJH685 50μM R08 exp433	1.74
Dimethyloxaloylglycine 100μM R05 exp229	1.82
Vemurafenib 6.6μM R02 exp89	1.94
Quercetin 20μM R08 exp517	2.13

Global Fraction of Cell Lines Where Essential: 78/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	1/28
bone	1/26
breast	8/33
central nervous system	2/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	3/20
lung	11/75
lymphocyte	1/16
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	1/29
uterus	1/5

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression