MSMO1

Entrez Summary: Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. {ECO:0000250|UniProtKB:P53045}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C-4 methylsterol oxidase activity
cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
alcohol biosynthetic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
organic hydroxy compound biosynthetic process
steroid metabolic process
alcohol metabolic process
fatty acid metabolic process
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process