MSTN
Gene Information
- Official Symbol: MSTN
- Official Name: myostatin
- Aliases and Previous Symbols: N/A
- Entrez ID: 2660
- UniProt: O14793
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016].
- UniProt Summary: Acts specifically as a negative regulator of skeletal muscle growth. {ECO:0000250|UniProtKB:O08689}.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| negative regulation of skeletal muscle tissue growth |
| negative regulation of myoblast proliferation |
| negative regulation of skeletal muscle cell proliferation |
| myoblast migration involved in skeletal muscle regeneration |
| negative regulation of skeletal muscle satellite cell proliferation |
| negative regulation of satellite cell differentiation |
| regulation of skeletal muscle tissue growth |
| negative regulation of skeletal muscle cell differentiation |
| skeletal muscle atrophy |
| striated muscle atrophy |
| muscle atrophy |
| response to gravity |
| negative regulation of skeletal muscle tissue development |
| skeletal muscle adaptation |
| regulation of myoblast proliferation |
| regulation of skeletal muscle satellite cell proliferation |
| myoblast migration |
| regulation of skeletal muscle cell proliferation |
| positive regulation of macrophage chemotaxis |
| regulation of skeletal muscle cell differentiation |
| positive regulation of macrophage migration |
| positive regulation of lamellipodium assembly |
| muscle cell cellular homeostasis |
| muscle cell migration |
| response to muscle activity |
| negative regulation of myoblast differentiation |
| regulation of macrophage chemotaxis |
| striated muscle adaptation |
| negative regulation of muscle hypertrophy |
| positive regulation of lamellipodium organization |
| cellular response to dexamethasone stimulus |
| regulation of lamellipodium assembly |
| muscle adaptation |
| negative regulation of insulin receptor signaling pathway |
| skeletal muscle tissue regeneration |
| negative regulation of cellular response to insulin stimulus |
| regulation of macrophage migration |
| response to testosterone |
| response to dexamethasone |
| regulation of lamellipodium organization |
| transforming growth factor beta receptor binding |
| regulation of granulocyte chemotaxis |
| ovulation cycle process |
| response to electrical stimulus |
| regulation of mononuclear cell migration |
| negative regulation of protein kinase B signaling |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of striated muscle tissue development |
| regulation of skeletal muscle tissue development |
| negative regulation of muscle organ development |
| negative regulation of muscle tissue development |
| regulation of myoblast differentiation |
| cellular response to glucocorticoid stimulus |
| SMAD protein signal transduction |
| regulation of muscle hypertrophy |
| cellular response to corticosteroid stimulus |
| regulation of pathway-restricted SMAD protein phosphorylation |
| tissue regeneration |
| regulation of insulin receptor signaling pathway |
| response to activity |
| ovulation cycle |
| regulation of cellular response to insulin stimulus |
| response to estrogen |
| positive regulation of leukocyte chemotaxis |
| cellular response to ketone |
| response to antineoplastic agent |
| positive regulation of plasma membrane bounded cell projection assembly |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of developmental growth |
| response to heat |
| regulation of leukocyte chemotaxis |
| response to ethanol |
| positive regulation of leukocyte migration |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| positive regulation of chemotaxis |
| response to glucocorticoid |
| cellular response to transforming growth factor beta stimulus |
| regeneration |
| response to corticosteroid |
| response to transforming growth factor beta |
| growth factor activity |
| heparin binding |
| cytokine activity |
| response to temperature stimulus |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| response to ketone |
| regulation of leukocyte migration |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of chemotaxis |
| regulation of protein kinase B signaling |
| response to alcohol |
| regulation of muscle system process |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of growth |
| negative regulation of kinase activity |
| rhythmic process |
| negative regulation of transferase activity |
| muscle organ development |
| muscle system process |
| response to xenobiotic stimulus |
| response to antibiotic |
| response to steroid hormone |
| regulation of developmental growth |
| signaling receptor binding |
| anatomical structure homeostasis |
| positive regulation of cell projection organization |
| developmental growth |
| growth |
| cellular response to drug |
| negative regulation of phosphorylation |
| muscle structure development |
| wound healing |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| response to toxic substance |
| negative regulation of intracellular signal transduction |
| positive regulation of cellular component biogenesis |
| cellular response to lipid |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| regulation of system process |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| protein homodimerization activity |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| HMS-I2 5μM R06 exp287 | -1.92 |
| Citral 75μM R06 exp275 | -1.8 |
| MS023 2μM R03 exp134 | 1.71 |
| 2-Methoxyestradiol 0.2μM R01 exp40 | 1.97 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.492 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18009
- Expression level (log2 read counts): -0.16
Expression Distribution
MSTN Expression in NALM6 Cells: -0.16
