MTA3

Gene Information

Official Symbol: MTA3
Official Name: metastasis associated 1 family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 57504
UniProt: Q9BTC8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 5μM R06 exp287	-1.83
Pimelic-diphenylamide-106 5μM R00 exp28	-1.77
Hydroxyurea 100μM R07 exp329	-1.73
MK2206 4μM R08 exp504	-1.7
Deguelin 0.05μM R02 exp69	1.89
UM0131023 0.05μM R05 exp248	2.24

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9876
Expression level (log2 read counts): 4.78

Expression Distribution

ELM2
BAH
GATA

NuRD complex
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
RNA polymerase II repressing transcription factor binding
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
positive regulation of mitotic cell cycle phase transition
positive regulation of cell cycle phase transition
histone deacetylase binding
positive regulation of mitotic cell cycle
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
transcription corepressor activity
protein-containing complex binding
transcription coactivator activity
positive regulation of cell cycle process
histone modification
covalent chromatin modification
positive regulation of cell cycle
chromatin binding
regulation of mitotic cell cycle phase transition
sequence-specific DNA binding
regulation of cell cycle phase transition
regulation of mitotic cell cycle
intracellular membrane-bounded organelle
chromatin organization
regulation of cell cycle process
zinc ion binding
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
chromosome organization
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process