MUL1

Gene Information

Official Symbol: MUL1
Official Name: mitochondrial E3 ubiquitin protein ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 79594
UniProt: Q969V5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697). {ECO:0000269|PubMed:18207745, ECO:0000269|PubMed:18213395, ECO:0000269|PubMed:18591963, ECO:0000269|PubMed:19407830, ECO:0000269|PubMed:22410793, ECO:0000269|PubMed:23399697, ECO:0000269|PubMed:24898855}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BVD-523 15μM R02 exp67	-2.62
Bleomycin 5μM R08 exp459	-2.52
Etoposide 1μM R00 exp19	-2.43
Bortezomib 0.05μM R00 exp7	-2.32
UM0129480 7μM R02 exp85	-2.08
Pimelic-diphenylamide-106 5μM R00 exp28	-2.06
Dinaciclib 0.007μM R07 exp355	-2.05
LB-100 4.1μM R02 exp72	-2.01
SNS-032 15μM R08 exp443	-1.99
Etoposide 10μM R00 exp20	-1.88
MS023 2μM R03 exp134	-1.78
RK-33 8μM R08 exp518	-1.75
Rotenone 20μM R00 exp34	-1.73
Docosahexaenoic-acid 50μM R07 exp356	1.86
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7930
Expression level (log2 read counts): 5.08

Expression Distribution

Gene	Correlation
POLR2J3	0.477
RUVBL2	0.447
MTCH2	0.444
SMG7	0.433
ZFAND5	0.415
MBTD1	0.401
RRP7A	0.401

negative regulation of defense response to virus by host
negative regulation of chemokine (C-C motif) ligand 5 production
negative regulation of mitochondrial fusion
regulation of chemokine (C-C motif) ligand 5 production
regulation of mitochondrial fusion
positive regulation of protein sumoylation
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of autophagy of mitochondrion in response to mitochondrial depolarization
negative regulation of type I interferon-mediated signaling pathway
positive regulation of mitochondrial fission
SUMO transferase activity
cellular response to exogenous dsRNA
mitochondrial fission
response to mitochondrial depolarisation
positive regulation of autophagy of mitochondrion
negative regulation of chemokine production
integral component of mitochondrial outer membrane
regulation of protein sumoylation
cellular response to dsRNA
regulation of mitochondrial fission
positive regulation of dendrite extension
negative regulation of defense response to virus
regulation of dendrite extension
regulation of type I interferon-mediated signaling pathway
regulation of defense response to virus by host
activation of JUN kinase activity
regulation of autophagy of mitochondrion
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
response to exogenous dsRNA
negative regulation of protein kinase B signaling
mitochondrion localization
protein destabilization
response to dsRNA
negative regulation of mitochondrion organization
negative regulation of innate immune response
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
protein sumoylation
regulation of mitochondrial membrane potential
regulation of mitochondrial membrane permeability