MVB12B

Entrez Summary: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Quercetin 20μM R08 exp517	-2.04
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.92
B02 10μM R08 exp453	-1.76
JQ1 0.8μM R08 exp435	-1.73

virus maturation
ESCRT I complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
virion assembly
intracellular transport of virus
host cell
transport of virus
multi-organism localization
multi-organism transport
ubiquitin binding
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
late endosome membrane
late endosome
vesicle
lipid binding
viral life cycle
endosome membrane
endosomal transport
early endosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
viral process
symbiotic process
interspecies interaction between organisms
cellular macromolecule catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
organic substance catabolic process