NAB2

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NCD2
NCD1

negative regulation of transcription by RNA polymerase III
positive regulation of tau-protein kinase activity
regulation of tau-protein kinase activity
regulation of transcription by RNA polymerase III
endochondral ossification
replacement ossification
Schwann cell differentiation
endochondral bone morphogenesis
peripheral nervous system development
regulation of epidermis development
myelination
ensheathment of neurons
axon ensheathment
bone morphogenesis
glial cell differentiation
bone development
gliogenesis
skeletal system morphogenesis
transcription corepressor activity
ossification
transcription factor binding
skeletal system development
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
regulation of protein kinase activity
regulation of kinase activity
animal organ morphogenesis
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
identical protein binding
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
negative regulation of transcription, DNA-templated
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process