NBEAL2

Entrez Summary: The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011].
UniProt Summary: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-2.04
MSC2530818 10μM R07 exp379	-1.92
YM155 0.001μM R08 exp432	-1.89
Docetaxel 0.002μM R01 exp45	1.8
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.81
THZ531 0.225μM R08 exp444	1.91
THZ531 0.11μM R07 exp409	2.03
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.46
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.59

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Beach
WD40

platelet formation
platelet morphogenesis
ficolin-1-rich granule membrane
tertiary granule membrane
myeloid cell differentiation
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
hemopoiesis
cell morphogenesis involved in differentiation
myeloid leukocyte activation
hematopoietic or lymphoid organ development
leukocyte activation involved in immune response
cell activation involved in immune response
immune system development
regulated exocytosis
cell morphogenesis
leukocyte mediated immunity
exocytosis
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
leukocyte activation
secretion by cell
endoplasmic reticulum
export from cell
cell activation
immune effector process
secretion
cell development
immune response
vesicle-mediated transport