NDUFA7

Entrez Summary: This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Sulforaphane 9μM R08 exp525	-1.77
SGC0649 7μM R03 exp150	-1.75

mitochondrial ribosome
NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
mitochondrial translation
oxidative phosphorylation
mitochondrial gene expression
cellular respiration
structural constituent of ribosome
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
translation
mitochondrial inner membrane
peptide biosynthetic process
generation of precursor metabolites and energy
mitochondrion organization
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
cellular protein-containing complex assembly
oxidation-reduction process
mitochondrion
phosphorylation
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression