NME7

Gene Information

Official Symbol: NME7
Official Name: NME/NM23 family member 7
Aliases and Previous Symbols: N/A
Entrez ID: 29922
UniProt: Q9Y5B8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
UniProt Summary: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9758
Expression level (log2 read counts): 4.12

Expression Distribution

Screen	Score
Mubritinib 0.2μM R02 exp65	1.71
Latrunculin-B 10μM R07 exp374	1.76

UTP biosynthetic process
GTP biosynthetic process
UTP metabolic process
CTP metabolic process
CTP biosynthetic process
guanosine-containing compound biosynthetic process
pyrimidine ribonucleoside triphosphate biosynthetic process
pyrimidine ribonucleoside triphosphate metabolic process
nucleoside diphosphate kinase activity
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine ribonucleotide biosynthetic process
purine nucleoside biosynthetic process
pyrimidine nucleoside triphosphate metabolic process
ribonucleoside biosynthetic process
purine ribonucleoside biosynthetic process
pyrimidine ribonucleotide metabolic process
GTP metabolic process
nucleoside biosynthetic process
guanosine-containing compound metabolic process
glycosyl compound biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
ribonucleoside triphosphate biosynthetic process
pyrimidine-containing compound biosynthetic process
purine ribonucleoside triphosphate metabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside metabolic process
pyrimidine nucleotide metabolic process
nucleotide phosphorylation
nucleoside triphosphate biosynthetic process
purine nucleoside metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
ribonucleoside metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process