NMNAT1

Entrez Summary: This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 54/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	1/26
breast	2/33
central nervous system	4/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	4/75
lymphocyte	7/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of apoptotic DNA fragmentation
nicotinamide-nucleotide adenylyltransferase activity
ATP generation from poly-ADP-D-ribose
nicotinate-nucleotide adenylyltransferase activity
negative regulation of DNA catabolic process
regulation of apoptotic DNA fragmentation
regulation of DNA catabolic process
negative regulation of execution phase of apoptosis
NAD biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
regulation of execution phase of apoptosis
pyridine-containing compound metabolic process
NAD metabolic process
oxidoreduction coenzyme metabolic process
negative regulation of DNA metabolic process
coenzyme biosynthetic process
negative regulation of neuron apoptotic process
ATP metabolic process
regulation of neuron apoptotic process
negative regulation of neuron death
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
negative regulation of cellular catabolic process
nuclear body
negative regulation of catabolic process
regulation of neuron death
regulation of DNA metabolic process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
positive regulation of MAPK cascade
response to wounding