NPSR1

Gene Information

Official Symbol: NPSR1
Official Name: neuropeptide S receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 387129
UniProt: Q6W5P4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	2.09
Nocodazole 0.2μM R00 exp24	2.13
HMS-I1 10μM R06 exp256	2.31
Nocodazole 0.2μM R02 exp64	2.49
R-DABN 8μM R03 exp111	2.5
DABN racemic mixture R03 exp93	2.58
SB743921 0.001μM R05 exp244	3.18
Rotenone 2μM R00 exp33	3.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14375
Expression level (log2 read counts): -2.74

Expression Distribution

vasopressin receptor activity
neuropeptide receptor activity
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport into cytosol
positive regulation of calcium ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
regulation of calcium ion transport into cytosol
neuropeptide signaling pathway
positive regulation of calcium ion transport
regulation of sequestering of calcium ion
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
positive regulation of transmembrane transport
regulation of calcium ion transport
positive regulation of ion transport
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of cation transmembrane transport
regulation of metal ion transport
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
regulation of ion transmembrane transport
divalent inorganic cation homeostasis
cellular metal ion homeostasis
regulation of transmembrane transport
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
regulation of ion transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
regulation of cellular localization
positive regulation of transport
chemical homeostasis
G protein-coupled receptor signaling pathway