NRIP1

Entrez Summary: Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008].
UniProt Summary: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. {ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DKK1 89ng/ml R08 exp477	-1.7
BI-6727 0.001μM R01 exp42	2.11

ovarian follicle rupture
ovulation from ovarian follicle
glucocorticoid receptor binding
retinoid X receptor binding
ovulation
nuclear hormone receptor binding
lipid storage
cellular response to estradiol stimulus
androgen receptor signaling pathway
histone deacetylase complex
ovulation cycle process
estrogen receptor binding
androgen receptor binding
circadian regulation of gene expression
ovulation cycle
intracellular steroid hormone receptor signaling pathway
female gonad development
development of primary female sexual characteristics
female sex differentiation
histone deacetylase binding
steroid hormone mediated signaling pathway
female gamete generation
response to estradiol
circadian rhythm
intracellular receptor signaling pathway
maintenance of location
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
gonad development
development of primary sexual characteristics
nuclear chromatin
transcription corepressor activity
sex differentiation
rhythmic process
transcription coactivator activity
lipid localization
response to steroid hormone
nuclear speck
reproductive structure development
reproductive system development