NVL

Entrez Summary: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011].
UniProt Summary: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). May play a role in 60S ribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 672/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	23/28
bone	25/26
breast	30/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	18/21
liver	19/20
lung	71/75
lymphocyte	11/16
ovary	23/26
pancreas	19/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	29/29
uterus	5/5

Expression Distribution

AAA
RuvB N

preribosome binding
regulation of protein localization to nucleolus
nuclear exosome (RNase complex)
telomerase holoenzyme complex
positive regulation of telomerase activity
regulation of telomerase activity
positive regulation of DNA biosynthetic process
ribosomal large subunit biogenesis
positive regulation of protein binding
regulation of DNA biosynthetic process
regulation of protein localization to nucleus
positive regulation of binding
positive regulation of DNA metabolic process
rRNA processing
regulation of protein binding
rRNA metabolic process
ATPase activity
ribosome biogenesis
regulation of DNA metabolic process
regulation of binding
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
regulation of cellular protein localization
positive regulation of transferase activity
nucleolus
RNA processing
regulation of cellular localization
regulation of transferase activity
regulation of protein localization
RNA binding
positive regulation of catalytic activity
ATP binding
RNA metabolic process
positive regulation of molecular function
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
membrane
gene expression