ONECUT2

Gene Information

Official Symbol: ONECUT2
Official Name: one cut homeobox 2
Aliases and Previous Symbols: N/A
Entrez ID: 9480
UniProt: O95948
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12307
Expression level (log2 read counts): -0.85

Expression Distribution

Screen	Score
CHIR-124 0.04μM R06 exp272	-2.05
Trametinib 10μM R02 exp83	-1.7

CUT
Homeobox

peripheral nervous system neuron development
peripheral nervous system neuron differentiation
endocrine pancreas development
pancreas development
peripheral nervous system development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of transforming growth factor beta receptor signaling pathway
regulation of cell-matrix adhesion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
endocrine system development
liver development
hepaticobiliary system development
negative regulation of cellular response to growth factor stimulus
epithelial cell development
regulation of cell-substrate adhesion
actin cytoskeleton
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cell fate commitment
regulation of cellular response to growth factor stimulus
cilium assembly
cilium organization
gland development
plasma membrane bounded cell projection assembly
DNA-binding transcription activator activity, RNA polymerase II-specific
cell projection assembly
positive regulation of cell migration
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
epithelial cell differentiation
regulation of cell adhesion
organelle assembly
neuron development
regulation of cell migration
regulation of cell motility
animal organ morphogenesis
regulation of locomotion