OR51E2

Entrez Summary: N/A
UniProt Summary: Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702). {ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 1
7TM GPCR Srsx

positive regulation of renin secretion into blood stream
melanocyte proliferation
intracellular organelle
regulation of renin secretion into blood stream
melanocyte differentiation
positive regulation of cAMP-mediated signaling
pigment cell differentiation
regulation of renal system process
positive regulation of blood pressure
developmental pigmentation
regulation of endocrine process
regulation of cAMP-mediated signaling
steroid hormone receptor activity
cellular response to fatty acid
positive regulation of blood circulation
response to fatty acid
epithelial cell proliferation
pigmentation
regulation of systemic arterial blood pressure
steroid hormone mediated signaling pathway
early endosome membrane
hormone-mediated signaling pathway
regulation of blood pressure
cellular response to steroid hormone stimulus
signaling receptor activity
cellular response to acid chemical
positive regulation of protein secretion
regulation of blood circulation
positive regulation of peptide secretion
response to steroid hormone
response to acid chemical
blood circulation
circulatory system process
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
detection of chemical stimulus involved in sensory perception of smell
olfactory receptor activity
positive regulation of establishment of protein localization
sensory perception of smell