ORM1

Gene Information

Official Symbol: ORM1
Official Name: orosomucoid 1
Aliases and Previous Symbols: N/A
Entrez ID: 5004
UniProt: P02763
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008].
UniProt Summary: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. {ECO:0000269|PubMed:17008009, ECO:0000269|PubMed:17321687}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-1.72
Nocodazole 0.02μM R00 exp23	1.7
Bortezomib 0.05μM R00 exp7	1.72
Cycloheximide 0.2μM R00 exp15	1.72
B02 10μM R08 exp453	1.74
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.79
Alpha-Amanitin 0.5μM R00 exp5	1.93
GSK626616 14μM R08 exp485	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13790
Expression level (log2 read counts): -4.01

Expression Distribution

positive regulation of tumor necrosis factor secretion
regulation of tumor necrosis factor secretion
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 secretion
acute-phase response
negative regulation of interleukin-6 production
regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta production
regulation of interleukin-1 secretion
tertiary granule lumen
positive regulation of interleukin-1 production
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
specific granule lumen
platelet alpha granule lumen
acute inflammatory response
regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
regulation of interleukin-1 production
platelet degranulation
positive regulation of cytokine secretion
regulation of interleukin-6 production
blood microparticle
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
regulation of cytokine secretion
positive regulation of protein secretion
negative regulation of cytokine production
positive regulation of peptide secretion
collagen-containing extracellular matrix
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
neutrophil degranulation
neutrophil activation involved in immune response
regulation of peptide secretion