OSBPL3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.98
Lenalidomide 20μM R07 exp375	-1.92
Vinblastine 0.015μM R05 exp208	1.72
Dimethyloxaloylglycine 11μM R07 exp314	1.83
Nocodazole 0.2μM R00 exp24	2.63
R-DABN 8μM R03 exp111	2.63
HMS-I1 10μM R06 exp256	2.84
Rotenone 2μM R00 exp33	3.27
SB743921 0.001μM R05 exp244	3.33
Nocodazole 0.1μM R03 exp94	4.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
Oxysterol BP

sterol binding
sterol transporter activity
perinuclear endoplasmic reticulum
filopodium tip
bile acid biosynthetic process
bile acid metabolic process
cholesterol binding
sterol transport
steroid biosynthetic process
organic hydroxy compound transport
lipid binding
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
nuclear membrane
steroid metabolic process
lipid transport
carboxylic acid biosynthetic process
organic acid biosynthetic process
lipid localization
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
endoplasmic reticulum membrane
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process
membrane