OST4

Entrez Summary: N/A
UniProt Summary: Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient N- glycosylation. Specifically involved in maintaining stability of STT3A-containing OST complexes. {ECO:0000269|PubMed:23606741, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.71
Rapamycin 10μM R00 exp30	-1.79
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.74
Tubacin 1.6μM R07 exp416	-1.71
Alpha-Amanitin 0.5μM R00 exp5	-1.7
THZ531 0.11μM R07 exp409	1.78
Dinaciclib 0.007μM R07 exp355	2.03
Arsenate 40μM R06 exp264	2.48
RO-3307 4.7μM R02 exp80	2.53
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.67
Tunicamycin 0.04μM R07 exp418	3.14
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	3.46

Global Fraction of Cell Lines Where Essential: 16/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	2/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/29
uterus	0/5

Expression Distribution

oligosaccharyltransferase complex
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
peptidyl-amino acid modification
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process