OTUD3

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. {ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein K6-linked deubiquitination
protein K27-linked deubiquitination
protein K11-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of protein kinase B signaling
thiol-dependent ubiquitinyl hydrolase activity
thiol-dependent ubiquitin-specific protease activity
protein stabilization
regulation of protein kinase B signaling
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
negative regulation of intracellular signal transduction
protein modification by small protein conjugation or removal
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of intracellular signal transduction