OTUD4

Gene Information

Official Symbol: OTUD4
Official Name: OTU deubiquitinase 4
Aliases and Previous Symbols: N/A
Entrez ID: 54726
UniProt: Q01804
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010].
UniProt Summary: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin. {ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11300
Expression level (log2 read counts): 7.37

Expression Distribution

Screen	Score
Ethanol 0.01 R05 exp234	-1.81
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.76
QNZ 0.01μM R05 exp241	2.5

regulation of protein K48-linked deubiquitination
positive regulation of DNA demethylation
negative regulation of interleukin-1-mediated signaling pathway
regulation of DNA demethylation
regulation of interleukin-1-mediated signaling pathway
Lys63-specific deubiquitinase activity
regulation of protein deubiquitination
protein K63-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of toll-like receptor signaling pathway
molecular adaptor activity
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
regulation of toll-like receptor signaling pathway
thiol-dependent ubiquitin-specific protease activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
positive regulation of DNA metabolic process
regulation of protein modification by small protein conjugation or removal
protein deubiquitination
protein modification by small protein removal
regulation of DNA metabolic process
negative regulation of immune system process
regulation of innate immune response
regulation of response to biotic stimulus
regulation of proteolysis
regulation of defense response
innate immune response
regulation of multi-organism process
defense response to other organism
protein modification by small protein conjugation or removal
regulation of response to external stimulus
regulation of immune response
negative regulation of signal transduction
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
negative regulation of cell communication