P2RY11

Entrez Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-2536 0.0042μM R03 exp95	-1.91
ETC-159 50μM R08 exp480	1.7
Ethanol 0.01 R05 exp234	1.9
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.73

ATP-activated adenosine receptor activity
neuronal signal transduction
adenosine receptor signaling pathway
cellular response to ATP
G protein-coupled purinergic receptor signaling pathway
purinergic receptor signaling pathway
response to ATP
neurotransmitter receptor activity
activation of adenylate cyclase activity
cellular response to nutrient
phospholipase C-activating G protein-coupled receptor signaling pathway
response to organophosphorus
calcium-mediated signaling
response to purine-containing compound
signaling receptor activity
response to nutrient
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
second-messenger-mediated signaling
cellular response to drug
response to nutrient levels
response to extracellular stimulus
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
response to organic cyclic compound
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
defense response
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound
intracellular signal transduction